Prevalence of congenital heart defects in patients with Down's syndrome.
نویسنده
چکیده
Down’s syndrome (DS) is the most frequent chromosomal aberration among newborns, with an incidence of 1/660 live births; trisomy 21 occurs in 95% of cases due to maternal meiosis I non-disjunction, resulting in three full copies of chromosome 21 in each cell. Of these cases, 4% are due to parental/de novo translocation and 1% is due to mosaicism. Frequency of congenital heart defects (CHDs) in children with DS varies greatly in the literature, from 20 to over 60%.1,2
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ورودعنوان ژورنال:
- Jornal de pediatria
دوره 85 5 شماره
صفحات -
تاریخ انتشار 2009